10 Deadliest Sharingan Victims in Itachi Uchiha’s History

From a young age, Itachi Uchiha achieved astonishing feats, hailed as a shinobi prodigy by both the Hidden Leaf Village and the Uchiha Clan. Beyond his exceptional combat prowess and mastery of ninja weaponry, Itachi was armed with the formidable visual power of the Sharingan.

His genjutsu could incapacitate foes without him ever laying a finger on them, and his specialized Sharingan techniques were lethal enough to bring down any opponent.

Here are ten victims who fell to the ferocity of Itachi Uchiha’s Sharingan.

1. Itachi Uchiha vs. The Strongest Kunoichi of the Anbu Root

While resting during a mission to track down fugitives in the forest, Itachi and Shisui were startled by a violent clash. Three of Danzo’s Root Anbu were attempting to assassinate one of the Hokage’s personal Anbu. Refusing to stand by, Itachi and Shisui intervened to protect the Hokage’s operative, drawing the immediate ire of Danzo’s assassins.

A battle was inevitable. Itachi faced off against the strongest kunoichi of the Root organization, while Shisui took on the remaining two Anbu.

Armed with a single sword and a kunai, Itachi clashed against the kunoichi and her twin blades. The duel appeared evenly matched; a flawless exchange of parries where neither managed to land a decisive strike.

Though Itachi hadn’t trained his Sharingan since its initial awakening, he activated it instinctively in the heat of combat. From the very beginning, he scrutinized every kunai and shuriken the kunoichi threw, noticing nearly invisible threads attached to her weapons.

With the Sharingan, Itachi effortlessly read and evaded her assault. Predicting the trajectory of three incoming shuriken, he thrust his sword perfectly through their center holes, pinning the weapons and his blade firmly into the dirt.

Standing effortlessly atop the hilt of his embedded sword, Itachi told the kunoichi he had seen through her entire strategy. She only laughed, mocking his arrogance, confident he hadn’t realized he was already standing dead center in her wire trap.

She severed a trigger thread, expecting the wires to brutally bind Itachi’s body. Instead, the trap violently backfired. The wires coiled and snapped tight around the kunoichi herself.

Itachi calmly explained how he had turned her trap against her. Recognizing the threads on her projectiles, he had subtly redirected their trajectories every time he deflected a strike. The snare she had meticulously woven to capture him had been silently rewoven by Itachi to capture her.

Ultimately, the strongest kunoichi of Danzo’s Root collapsed, rendered completely unconscious by her own trap.

2. Itachi Uchiha vs. Yagura Karatachi

After successfully assassinating a clan leader in the Hidden Mist Village on orders from the Akatsuki, Juzo and Itachi hurried to extract. However, their infiltration was compromised. They were quickly surrounded by the Fourth Mizukage, Yagura, alongside the village’s elite Tracker Ninja Unit.

A fierce skirmish erupted. Itachi’s Fire Style jutsu engulfed Yagura in flames, and together with Juzo, he swiftly dispatched the entire Tracker Unit. Enraged, Yagura tapped into his Tailed Beast power, entering his Three-Tails Chakra Mode to crush the intruders.

Harnessing the beast’s immense strength, Yagura punched Juzo away and struck Itachi with a Coral Jutsu. Rapidly growing coral encased Itachi’s arm, restricting his movements. As the transformed Yagura lunged for a finishing blow on the immobilized Uchiha, a quick-thinking Juzo swung his massive blade, deflecting the Mizukage and frantically attempting to shatter the coral binding Itachi.

Undeterred, Yagura fired a catastrophic Tailed Beast Bomb at them. Juzo tried to block it with the Executioner’s Blade, but the sheer force shattered the heavy sword, sending a broken shard piercing directly through his vitals. Juzo fell, critically wounded. The blast’s shockwave launched Itachi backward, though the impact shattered the coral on his body.

As Yagura prepared to fire another Tailed Beast Bomb to finish him, Itachi awakened his Mangekyo Sharingan and unleashed the Amaterasu for the very first time. The unextinguishable black flames struck their mark, incinerating Yagura’s Tailed Beast cloak. Screaming in agony, the Mizukage reverted to his human form and collapsed—unconscious and utterly defeated.

3. Itachi Uchiha vs. Orochimaru

Back when Orochimaru still resided in the Hidden Leaf, he secretly observed a young Itachi training. The boy intentionally lured himself into a blind-spot volley of kunai, only to flawlessly deflect them with shuriken, twisting his agile body so elegantly that not a single blade grazed him. Orochimaru was mesmerized by Itachi’s prodigal talent and deeply captivated by the power of the Sharingan.

Unsurprisingly, when both eventually found themselves in the Akatsuki, Orochimaru offered Itachi a warm welcome. He watched the young Uchiha with deep obsession, openly expressing his desire to partner with Itachi—which severely annoyed Itachi’s current partner, Juzo. Even after Juzo died, Orochimaru eagerly volunteered to replace him, leaving his own partner, Sasori, feeling bitterly disrespected.

One day, passing each other on a staircase, Orochimaru struck. As Itachi descended past him, the Sannin attacked from behind, binding Itachi’s body tightly with summoned snakes. With a sinister smile, Orochimaru declared his true intention: to claim Itachi’s body as his new vessel for eternal life.

But in a fraction of a second, the reality shifted. Itachi stood calmly in front of Orochimaru. He had cast a paralyzing genjutsu. When Orochimaru desperately attempted to form hand signs to break the illusion, Itachi moved with blinding speed, cleanly severing one of the Sannin’s arms.

Orochimaru could only marvel at the Sharingan’s terrifying power. Itachi coldly informed him that any jutsu would be utterly useless against those eyes. Having effortlessly humiliated one of Konoha’s legendary Sannin, Itachi paused, debating whether to kill Orochimaru or exploit him. Ultimately, luck favored the serpent, as Itachi allowed Kabuto to drag his master away to safety.

Yet, this wouldn’t be the last time Itachi left Orochimaru helpless. He defeated him twice.

Years later, when Sasuke exhausted his chakra fighting Itachi, the fragment of Orochimaru sealed within him broke free. A colossal, eight-headed white serpent erupted from the cursed seal on Sasuke’s neck. Orochimaru emerged from the beast’s mouth, coughing up the Kusanagi blade. He gloated, thanking Itachi for finally draining Sasuke’s chakra—the exact opportunity he had been waiting for to hijack Sasuke’s body.

Wasting no time, Itachi manifested his Susanoo and pierced Orochimaru with the Totsuka Blade. At first, Orochimaru mocked the seemingly weightless thrust. But his arrogance turned to sheer panic as he recognized the weapon. He realized too late that Itachi possessed the legendary sealing sword he had spent a lifetime searching for.

Pierced by the Totsuka Blade, Orochimaru was instantly sealed away, condemned to a world of eternal genjutsu.

4. Itachi Uchiha vs. Deidara

When Itachi, Kisame, and Sasori arrived at Deidara’s residence to recruit him into the Akatsuki, the rogue bomber showed zero interest. Unimpressed, Deidara told them to leave and stop interrupting the time he spent admiring his clay sculptures.

He passionately lectured them on his explosive clay jutsu, boasting about how his destructive creations were the ultimate form of art.

A challenge was issued. Itachi activated his Sharingan and challenged Deidara to a fight: if Itachi won, Deidara would join the organization. Deidara immediately molded two clay explosives, launching one as a direct distraction while secretly maneuvering the other for a blind-spot strike.

Though Itachi easily dodged the frontal assault, Deidara’s hidden clay successfully coiled around the Uchiha’s body, binding him tight.

Smug and disappointed by how easily Itachi had fallen, Deidara prepared to detonate the clay. But before he could trigger the explosion, Itachi calmly told him to look closer at his own body. Deidara gasped. In a jarring twist of reality, the explosive clay was tightly wrapped around his own body. He had almost blown himself to pieces.

Stunned, Deidara demanded to know when the genjutsu had been cast. Kisame casually remarked that the illusion began the very moment Deidara looked into Itachi’s eyes. Immobilized and defeated, Deidara looked up. He saw Itachi standing in the golden light of the setting sun, framed perfectly between his clay statues.

In that fleeting moment, Deidara couldn’t help but acknowledge that Itachi himself was a work of art—a realization that filled him with a bitter, lingering resentment toward his own admiration.

5. Itachi Uchiha vs. Kurenai

When Itachi and Kisame infiltrated the Hidden Leaf Village, they were intercepted by Kurenai and Asuma. A high-stakes clash ensued, pitting Itachi against Kurenai, and Kisame against Asuma.

Kurenai initiated the offensive, weaving a genjutsu that caused her physical form to slowly melt away into thin air. However, Itachi was already anticipating the illusion. Just before her body vanished entirely, he locked his Sharingan onto her.

Suddenly, a spectral tree sprouted behind Itachi, its thick roots violently coiling around his body and pinning him in place. Kurenai materialized from the bark, phasing out of the trunk just above him. Bound and helpless, Itachi simply craned his neck to look up at her.

Refusing to waste the opening, Kurenai lunged with her kunai for a lethal strike. But in the blink of an eye, the entire scene inverted. The phantom roots whipped around and bound Kurenai instead, immobilizing her exactly as they had done to him. Itachi stood freely before her, coldly noting that a genjutsu of her caliber would never work on him.

As Itachi raised his kunai to end her life, Kurenai desperately bit her own lip. The sharp pain shattered the genjutsu, allowing her to duck under Itachi’s fatal slash. Still, Itachi’s reflexes were merciless. He instantly followed up with a brutal kick, launching Kurenai backward and sending her crashing into the river below.

6. Itachi Uchiha vs. Kakashi Hatake

As Asuma and Kurenai began to get overwhelmed by the formidable Akatsuki duo, Kakashi arrived just in time as backup.

Holding a kunai to Itachi’s neck, Kakashi demanded to know their motive for infiltrating the village. Itachi gave a vague reply about seeking something, refusing to elaborate. He then readied a shuriken as a clever feint; his true strike was a Water Style attack erupting from beneath Kakashi’s feet. However, the veteran Copy Ninja saw through it, instantly countering with a Water Jutsu of his own.

After Kakashi swiftly pulled Kurenai away from Itachi’s exploding shadow clone, he realized the Uchiha was preparing a catastrophic genjutsu. He barked an order for Asuma and Kurenai to close their eyes. Relying on his own Sharingan, Kakashi believed he could withstand the optical assault. Itachi calmly corrected him, warning that a standard Sharingan stood absolutely no chance against the Mangekyo.

Kakashi was instantly dragged into Itachi’s ultimate illusion: the Tsukuyomi. Itachi explained that within this genjutsu, he had absolute control over space, mass, and time. Though the real-world duration would be brief, Itachi promised Kakashi he would be trapped and relentlessly impaled by swords for three entire days.

For 72 grueling hours, Kakashi endured the agonizing sensation of cold steel tearing through his body over and over. In the Tsukuyomi, a single second in the real world felt like hours, or even days. Though it occurred entirely within the mind, the sheer pain Kakashi experienced was indistinguishable from reality.

When the jutsu finally broke, Kakashi’s rigid body immediately collapsed, utterly exhausted. As he fell, a chilling realization washed over him: he couldn’t fathom why Itachi hadn’t simply killed him. He knew with absolute certainty that Itachi could have ended his life easily inside that illusion, had he truly wanted to.

7. Itachi Uchiha vs. Sasuke Uchiha

Tasked by the Akatsuki to kidnap Naruto, Itachi and Kisame infiltrated the Leaf and tracked down their target. However, Sasuke, having caught wind of his older brother’s presence in the village, managed to intercept them during their attempt.

Seeing Itachi face-to-face, Sasuke was consumed by blinding rage, his desire for vengeance igniting instantly. His entire existence and sole purpose in life revolved around murdering Itachi.

Sasuke charged up a Chidori and sprinted recklessly at his brother. But Itachi effortlessly caught the screeching lightning blade with a single hand. With a cruel twist, he fractured Sasuke’s wrist, sending the young boy screaming in agony as he crumpled to the floor.

Suddenly, Jiraiya arrived, narrowly saving Naruto from Kisame’s vicious Samehada strike. The legendary Sannin declared he would kill the Akatsuki intruders on the spot. But Sasuke stubbornly ordered Naruto and Jiraiya to stay out of his fight. Forcing himself up from the floor, he challenged Itachi once more, only to be subjected to a merciless, one-sided beatdown.

To finish it, Itachi trapped Sasuke in the Tsukuyomi. Sasuke was forced to endure his worst trauma all over again, reliving the agonizing Uchiha Clan massacre on a continuous loop for 24 hours. The intense psychological torture completely shattered his mind, causing his battered body to collapse helplessly. His desperate bid for revenge ended in total failure, leaving him with a broken arm, fractured ribs, and devastating mental trauma.

8. Itachi Uchiha vs. Naruto Uzumaki

Upon hearing the news that Sasuke had successfully killed Orochimaru, Naruto was perplexed as to why his friend hadn’t immediately returned to Konoha. Jiraiya deduced that Sasuke was likely hunting Itachi to fulfill his revenge before even considering heading home.

In response, Tsunade and Kakashi mobilized a Konoha pursuit squad. Their mission was to track down and capture Itachi, hoping to hand him over to Sasuke, confident that pursuing the older brother would inevitably lead them to the younger.

As Naruto deployed his Multi-Shadow Clones to scour the landscape for Sasuke, his true body unexpectedly stumbled upon Itachi deep within the forest. Itachi immediately stated he had no intention of capturing Naruto; he merely wanted to talk.

Refusing to trust him, Naruto ambushed Itachi from behind with two clones, but the Uchiha swatted them away with effortless ease.

Naruto quickly recalled the golden rules for fighting a Sharingan user: in a one-on-one, flee; in a two-on-one, attack their blind spot. Yet, he knew fighting Itachi was a terrifyingly complex ordeal, as the man could trap opponents in a genjutsu simply by moving his finger. Naruto stood his ground, fully on guard.

Itachi pointed out that Naruto was currently alone and asked why he hadn’t tried to run. Naruto boldly declared he could summon thousands of clones and had zero intention of fleeing. He was dead-set on capturing Itachi, knowing it was the only way to reach Sasuke.

Naruto bolted forward to attack. Smoothly and instantly, Itachi trapped him in a genjutsu with a mere flutter of his cloak. Inside the illusion, Naruto found himself swarmed by a dense murder of crows. By the time the hallucination broke, Naruto crashed heavily into the dirt.

Fortunately, Itachi truly didn’t intend to capture him—he only wanted to speak. Leaving a bewildered Naruto behind, Itachi departed. Naruto was left profoundly confused by his behavior, perfectly aware that Itachi could have easily taken him away if he had wanted to.

9. Reanimated Itachi Uchiha vs. Reanimated Nagato

Under the direct control of Kabuto’s Reanimation Jutsu (Edo Tensei), Nagato proved to be a devastating force. Utilizing the Preta Path, he absorbed the chakra from Killer Bee’s Eight-Tails cloak right through a punch to his stomach, restoring his body to full power. Meanwhile, Naruto found himself ensnared by the tail of Nagato’s invisible Giant Chameleon summon. Seizing the moment, Nagato utilized the Human Path to begin ripping Naruto’s soul directly from his body.

Desperate, Naruto thrust a Rasengan forward, but Nagato seamlessly absorbed it with the Preta Path. Nagato then summoned the King of Hell, preparing to feed it Naruto’s extracted soul. Simultaneously, he manifested the mechanized, extra limbs of the Asura Path to violently choke and bind Killer Bee, who had rushed in to help. Naruto was seconds away from having his soul extracted, and Bee was staring down the barrel of a lethal laser blast.

Unbeknownst to Nagato, Itachi launched a perfectly timed strike from his blind spot. He hurled kunai with lethal precision, blinding the Rinnegan eyes of both the Chameleon and the King of Hell. With their shared field of vision severed, Nagato couldn’t anticipate the surprise attack from Itachi’s Susanoo. The massive ethereal blade cleanly severed Nagato’s mechanical arms holding the hostages, allowing Itachi to scoop Naruto and Bee to safety within his Susanoo’s protective grip.

Forced into a corner, Nagato launched a black sphere into the sky, initiating the Planetary Devastation (Chibaku Tensei). The jutsu generated an overwhelming gravitational pull, tearing up the earth beneath Itachi, Bee, and Naruto, dragging them upward into the rapidly forming celestial sphere meant to entomb them.

Hearing Naruto’s story of escaping the jutsu previously through the Nine-Tails’ rampage, Itachi formulated a counter-strategy. He ordered Naruto and Bee to simultaneously unleash their strongest long-range jutsu. Even if their aim wasn’t perfect, the gravitational pull would automatically suck their attacks right into the core. The combined apocalyptic force of their three ultimate strikes successfully shattered the Planetary Devastation.

In the ensuing chaos, Itachi’s Susanoo suddenly lunged, thrusting the Totsuka Blade straight through Nagato’s body. Defeated, Nagato was permanently sealed away into a peaceful, eternal genjutsu slumber by the mythic sword.

10. Itachi vs. Kabuto

Having broken free from Kabuto’s Edo Tensei control, Itachi operated on his own free will. He immediately tracked down Kabuto’s hideout to completely shut down the Reanimation Jutsu wreaking havoc across the Fourth Great Ninja War.

Shortly after, Sasuke arrived at the scene. Sasuke demanded the truth about Tobi’s claims—that Itachi had massacred the Uchiha Clan on the direct orders of the Leaf’s higher-ups. Itachi told him he would have to wait for those answers; he would only reveal the truth after they defeated Kabuto.

But Kabuto was far from an easy target. Having trained in the Ryuchi Cave, he had mastered Sage Mode. He confidently proclaimed he had evolved past Orochimaru’s snake form to become a perfect Sage, achieving the form of a Dragon.

Kabuto launched his White Rage Jutsu, generating a blinding light and an excruciating sound that left both Itachi and Sasuke paralyzed inside their Susanoo. Moving freely in his Sage Mode, Kabuto lunged to assassinate Sasuke. Thankfully, Itachi shifted his Susanoo’s arm to block the lethal strike. Kabuto dispelled the jutsu, assuming Itachi could somehow detect him, though Itachi calmly admitted he had simply guessed Kabuto would prioritize targeting Sasuke first.

Recalling a childhood memory of hunting a wild boar, Itachi instructed Sasuke to use the exact same tactical formation. Following his brother’s lead, Sasuke fired a Susanoo arrow that pinned Kabuto’s tail to a rock, leaving him dangling upside down. But as Itachi moved in for the strike, Kabuto snatched Sasuke’s discarded sword from the ground and brutally impaled Itachi through the stomach.

This was the opening Itachi needed. He used his Sharingan to record this exact physical sensation as a file for the Izanami—”Scene A1.” Instead of dying, the impaled Itachi burst into a flock of crows. Materializing beside him, Itachi seized the sword from Kabuto and sliced off one of his horns. Scene A1 was securely saved.

Kabuto laughed, reminding them that killing him wouldn’t stop the Reanimation Jutsu—only he could undo it. He had even shut off his vision entirely, rendering visual genjutsu useless and making him confident he couldn’t be beaten. Itachi then explained to Sasuke that the Uchiha possessed the Izanami—a technique that bypassed eye contact completely but carried the steep risk of permanent blindness. He revealed he was already preparing it against Kabuto.

Desperate to crush them, Kabuto began unleashing the horrific abilities of others he had absorbed. He used Sakon’s power to manifest Jirobo, casting an Earth Style jutsu that bypassed their protective Amaterasu barrier. He manifested Kidomaru to fire spider webs, which the brothers incinerated with Amaterasu. He launched Kimimaro’s bone spikes, which the dual Susanoo completely smashed.

He then utilized Tayuya’s phantom flute, successfully trapping both brothers in an auditory genjutsu. Seeing them paralyzed, Kabuto launched Orochimaru’s colossal white snake to absorb them. In a brilliant display of synergy, Itachi and Sasuke locked eyes, casting genjutsu on each other to shatter Tayuya’s illusion. Freed, they summoned their Susanoo and completely crushed the white snake’s assault.

Declaring his final move, Itachi announced the activation of Izanami. Kabuto suddenly burst from the severed white snake’s mouth and slashed Itachi’s body. With this crucial physical touch, the condition to trigger Izanami was perfectly met.

Itachi then used his Sharingan to record “Scene B.” As Sasuke exhaled a massive Fire Style jutsu, Kabuto countered with a Water Style attack that extinguished the flames. Water splashed across the battlefield, and a single drop fell onto Kabuto’s shoulder. Scene B was locked in.

Next, Itachi recorded “Scene A2.” As Kabuto violently thrust his sword through Itachi’s approaching body, Itachi’s eye suddenly lost its light and went blind—the toll of the Izanami. The impaled Itachi once again burst into a flock of crows, seized Kabuto’s sword, and sliced off his horn. This sequence was successfully stored as Scene A2.

Finally, Itachi recorded “Scene C.” As Kabuto marched confidently toward Sasuke and Itachi, his foot stepped on a fallen crow feather. Scene C was saved to the Izanami file.

From that moment on, Kabuto could attempt any new tactic or attack he wanted against the brothers, but the outcome was relentlessly the same: he would stab Itachi, Itachi would dissolve into crows, and Itachi would sever his horn. Kabuto and Sasuke would clash with Water and Fire jutsu, and a drop of water would land on Kabuto’s shoulder. Kabuto would charge forward, step on a crow feather, stab Itachi, and watch him turn to crows before his horn was cut off again.

Kabuto was completely trapped in an infinite, inescapable loop of repeating events. He experienced a maddening déjà vu as Scene A1 bridged to Scene B, Scene B flowed into Scene C, Scene C connected to Scene A2, and Scene A2 seamlessly looped back into Scene A1. It was a terrifying display of visual prowess, paid for with the permanent sacrifice of one of Itachi’s eyes.

In the real world, Kabuto’s physical body simply stood frozen in place. Yet inside his mind, he was endlessly fighting a looping battle against Itachi and Sasuke. According to Itachi, it was still possible for Kabuto to break free from the Izanami. However, the sole condition for his release was that he had to acknowledge his past sins and let go of his twisted desire to absorb others’ abilities to make himself whole. If he repented, accepted his true self, and chose to become a better person, the loop would finally break.